Below are a few articles and clippings that are the tip of the iceberg on this topic of massive scale and diversity. If you haven’t come across the below, I hope it will add to your knowledge.
Fortune Magazine feature article on painkillers and their use, history, and future. “254 million prescriptions for opioids were filled in the U.S., according to Wall Street analysts Cowen & Co. Enough painkillers were prescribed to ‘medicate every American adult around the clock for a month’”